|
Potency preserved with
Cialis
Cialis is the hottest PDE-5 (phosphodiasterase-5)
inhibitors in the market today for the patients of erectile
dysfunction. It’s sales have crossed those of
the earlier market leader Viagra and today Cialis is
the number one brand in key markets such as France.
What really makes Cialis
the most preferred erectile dysfunction drug today?
Before we answer that firstly let is
understand, what is erectile dysfunction? Erectile dysfunction
is defined as the inability to ensure or sustain an
erection for satisfactory sexual intercourse. It occurs
in 50% of men over the age of 40. If affects 180 million
men all over the world. What is most shocking is that
hardly 5% of them seek treatment.
How does erectile dysfunction occur?
There are basically two reasons for erectile
dysfunction. Firstly erectile dysfunction can happen
because of poorly functioning blood vessels. The blood
vessels that supply blood to the penis do not dilate
properly as they are clogged with excess fat or other
reasons. This occurs in 90% of the people with erectile
dysfunction. Secondly due to psychological reasons such
as stress, depression, etc erectile dysfunction can
also happen. This happens in 10% of the people with
erectile dysfunction. Erectile dysfunction leads to
considerable loss of potency and further on leads to
loss of self esteem.
Cialis was developed by the biotech company ICOS and
marketed all over the world by world renowned pharmaceutical
company Lilly. Cialis
contains Tadalafil, the second generation PDE-5 inhibitor.
It effectively inhibits the enzyme Phosphodiasterase-5,
which is responsible for the degradation of the enzyme
cGMP(cyclic guanosine monophosphate) which through a
series of reactions is responsible for the production
of nitric oxide. Nitric oxide is a powerful vasodilator,
which causes dilatation of the blood vessels that supply
blood to the penis. The penis fills with blood and we
have an erection due to hydraulic pressure.
In a review article by Dr. Porst H. published in the
journal - Urological Practice, the benefits of Cialis
were clinically documented. In the European daily-dosing
trial, the efficacy rates were up to 93% for successful
sexual intercourses with completion in the 50-mg dose
in patients with mild to moderate erectile dysfunction
(ED). In two different dose-ranging studies with 2-25
mg taken as needed, efficacy rates of up to 88% improvement
in erections and up to 73% successful sexual
intercourses with completion were achieved.
In a placebo-controlled, fixed-dose (10- and 20-mg)
trial in diabetic patients on Cialis, improved erections
of 56% and 64% were reported compared with 25% after
placebo. Clearly, when it comes to diabetic patients,
there is a definite advantage with Cialis. However the
US-FDA has warned that diabetics using Cialis must be
careful as it is known to cause vision related disturbances.
Drug-related adverse effects are seen, with headache
in up to 23% of patients (placebo, up to 17%), dyspepsia
in up to 11% (placebo, up to 7%), back pain in up to
4.7% (placebo, 0%), and myalgia in up to 4.1% (placebo,
up to 2.4%), were mostly mild to moderate. Neither drug-related
serious cardiovascular adverse events nor color vision
disturbances
Since PDE5 inhibitors such as tadalafil may cause transiently
low blood pressure (hypotension), organic nitrates should
not be taken for at least 48 hours after taking the
last dose of tadalafil. Using nitrates within this timeframe
may increase the risk of life-threatening hypotension.
The long half-life (>17 h), with a comfortably long
window of opportunity, releases couples from the need
to schedule sexual activities (as they would plan their
daily schedule) and therefore provides the highest amount
of spontaneity for sexual activities. On tablet of Cialis
is sufficient for more than 36 hours. Sex, thus become
a fun activity that adds value to the relationship.
The tablets of Cialis are yellow, film-coated, and
almond-shaped, and are produced in 5, 10, or 20mg doses.
A 20mg dose of Tadalafil is comparable to a 100mg dose
of Viagra.
This clearly shows the potency of Cialis.
There is a lot of competition between sites that sell
Cialis. This competition drives down the prices. One
should be very careful, while if one wants to buy Cialis.
A very popular website where cheap Cialis is available
is Cialis Online. At this site you will get attractive
bargains for Cialis – even as much as 50% on the
marked price.
If you are a man with erectile dysfunction or a spouse
of the same - ensure potency is preserved with Cialis.
More information on Cialis is available at Cialis.com.
|
