Genesis
The historical progress of Cialis: In
1993, Pharmaceutical co. ICOS started its research on
a compound IC351 that inhibits the PDE5 enzyme.
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Clinical pharmacology
How Cialis works?
The penis gets erect during sexual stimulation when
increased blood flows to the penis resulting from
relaxation of penile arteries and corpus cavernosal
smooth muscle. This is due to the release of nitric
oxide (NO) from nerve terminals and endothelial cells
which in turn leads to the synthesis of cGMP in smooth
muscle cells.
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Cialis Clinical Trials
Cialis was studied in general ED
population in 7 random, multi-centered, double-blinded,
placebo-controlled , parallel-arm designed of 12 weeks
duration. The studies aimed to check the primary efficacy
and safety of Tadalafil. Two studies were conducted
in United States and five were conducted outside the
United States . Additional studies were also conducted
involving Ed patients
with Diabetes Mellitus and those who undergone
prostrate surgery.
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Cialis Side Effects
Cialis was administered to over 4000 subjects (aged 19 to 86
years) during clinical trials worldwide. Over 230 patients
were treated for longer than one year and over 720 patients
were treated for over 6 months.
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Drug Interactions
Effect of other drugs on Cialis
Cytochrome P450 Inhibitors - CIALIS is predominantly
metabolized by CYP3A4. Studies have shown that drugs
that inhibit CYP3A4 can increase Tadalafil exposure
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Contraindications
Cialis is known to contradict with the following medications:
Nitrates - Cialis is not recommended for patients using
any form of organic nitrate, either regularly and/or
intermittently.
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