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ICOS gets the Cialis word out
January 16, 2004

Doctor's offices are the first stops in the Bothell biotech's strategy of advertising its erectile dysfunction drug to American men.

BOTHELL -- The battle between ICOS Corp.'s Cialis and rival erectile dysfunction drugs may not have hit the TV airwaves yet, but it has arrived at the doctor's office.

Richard Berger, a professor of urology at the University of Washington who also practices at the school's medical center, got a visit Wednesday from Cialis representatives.

The sales reps, who have been deployed across the nation by Bothell-based ICOS and its partner, Eli Lilly & Co., are touting the drug's advantages over the more-established and better- known Viagra, Berger said.

Patients also are beginning to ask for the new drug, he added.

"There are people asking about it, and I've written some prescriptions," Berger said.

While U.S. sales of Cialis have begun, investors are still wondering when they'll see the first Cialis commercials on TV, especially as ads for its competitors are hard to avoid.

ICOS' only recent comments on its ad strategy came earlier this week from Paul Clark, the company's chief executive officer. Speaking at an investors conference in San Francisco, Clark said he expects the first television commercials will run in the next two months.

He said ICOS and Lilly are waiting for the U.S. Food and Drug Administration to approve ads that include detailed information about Cialis' benefits and side effects, Clark said.

That would differentiate them from frequent ads running for Levitra, a rival that lasts about four hours like Pfizer Inc.'s Viagra. Levitra's makers, GlaxoSmithKline and Bayer, are running ads that give little information.

But some investors would like to see similar ads on the air for Cialis, arguing that promoting the brand name, even without much other information, can't hurt. The makers of Viagra and Levitra each spent more than $31 million on advertising in the month before Cialis got approval, according to the Verispan market research firm.

Paul Latta, an analyst with McAdams Wright Ragen Inc. in Seattle, said he tends to sympathize with that argument.

"I generally come down on the side of now rather than later," Latta said. "In branding, it is of value to get the name out there."

However, Latta said he sees merits in waiting for approval of more informative ads. After all, Cialis' differences from Viagra and Levitra are considered its biggest selling point. The drug can remain effective up to 36 hours after a man takes it and has fewer side effects than its competitors.

While TV commercials are the most visible way to promote a drug to a mass audience, Cialis is not unknown among the doctors and potential patients, Latta added.

"It may not be on TV on the NFL playoffs, but it's all over the place," he said.

The company has been busy with lower-profile marketing directly to doctors. Clark said sales representatives for ICOS and Lilly began visiting doctors the day after the U.S. Food and Drug Administration gave final approval to Cialis. Berger and other urologists have received numerous informational mailings about the drug.

There also has been ample media attention on the new competitors to Viagra, including this week's Time magazine, which focuses on the sex lives of older adults. Type "Cialis" into the Google search engine, and it comes up with more than 1.8 million hits, including plenty of online sites selling fake versions of the drug.

Clark said he's happy with the "solid start" ICOS and Lilly have with Cialis, as the first shipments went to pharmacies just two days after FDA approval came Nov. 21.

A single dose of Cialis costs about $14 at a Bothell Walgreen's drugstore, comparable to the price for Viagra.

Just how many patients are asking for prescriptions of the new drug, however, is still hard to gauge.

According to Verispan, Cialis had captured just a sliver of the market as of Jan. 2. However, of patients who switched between erectile dysfunction drugs, more than 23 percent went to Cialis. Nearly 8 percent of patients taking erectile dysfunction drug for the first time went with Cialis, Verispan reported. ICOS and Latta warn that because those figures were gathered around the holidays, they don't represent a typical period of time.

In Europe, where Cialis has been on the market since last February, the drug has made further inroads against Viagra.

According to ICOS' latest market data, 35 percent of erectile dysfunction prescriptions written in France as of November were for Cialis. In Germany and Australia, the drug also had at least 30 percent of the market share.

Because advertising for prescription drugs is banned in the European Union, ICOS and Lilly are using different tactics to reach potential patients. For example, the companies are organizing a series of events to "emotionally connect men with their partners." The first event, a private concert in Monaco featuring the band Blondie and opera tenor Jose Carreras, takes place Feb. 7.

In Britain, Cialis' makers have sponsored radio talk shows focusing on men's health and erectile dysfunction.

source:-http://www.heraldnet.com

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