Peyronies

Introduction

Peyronies disease is an uncommon sexual dysfunction that makes to having sex difficult and painful due to bent penis during erection. It is characterized by a hard, fibrous layer of scar tissue that normally develops under the skin or the upper or the lower side of the penis so as it gets erected the scar tissue pulls the affected area off at an angle gives rise to the curved penis. Francois de la Peyronie, a French surgeon was the first to have noticed the disease in the year 1743.

Indications

The indications of Peyronies disease may develop more slowly or might appear overnight. These may include:-

• Painful erection.
• A bend or curve in your penis during erection.
• Inflammation under the skin of the pennies that develops into hardened scar tissue.
• Narrowing of the diameter of the pennies during erection.
• Impaired ability to obtain an erection (erectile dysfunction).

Risk Factors

Peyronies disease is indeed an uncommon disorder, yet some factors are likely to increase the risk.

• Age:- Aging may diminish the penile elasticity and increase the chance of injury and the development of Peyronies disease.
• Heredity:- Although heredity is not the only factor responsible for the determination of Peyronies disease , yet it plays an important role in determining the one who is likely to be affected by it.
• Conditions involving hardened tissues:- Some men with Peyronies disease experience hardened tissue in other areas of the body, such as the hands or the feet. A cod like thickening across the palm the finger to pull inward known to be Dupuyten’s contracture may also be associated with Peyronies disease.

Complications

The complications involved with the Peyronies disease can be immense as it can make intercourse from being painful and difficult to almost impossible. Peyronies disease can have strong psychological impact as it degrades the morale and the self esteem of the male partner. In addition to this it adds to the emotional distress that puts strain on the married life or the relationship and makes attempt at sexual activity with your partner stressful and frustrating.

Peyronies Treatment

A lot of medications have been tried out for the treatment of Peyronies. The most prevalent ones being Vitamin E, Potaba, Colchicine, Verapamil and Collagenase. Apart with these treatments, surgical methods can also be very handy for people suffering from Peyronies disorder. One needs to fulfill the basic criteria before opting for the surgical treatment as additional actions are possible only when bending or deformity is severe enough to seriously interfere with sexual function or intercourse.

Lot of variation has been used for the treatment of Peyronie's disease. It has shown positive results in some patients but for the mejority the medication seems to make minor difference. Difference in treatment outcome and the resulting lack of consensus regarding the drug(s) of choice reflects in part an uncertainty with strategy.

While doctors can't say with precision what causes the disorder in each individual case, there does seem to be a common disease-producing process in all men. The major question of concern is,where, in this complex spectrum extending from early wound healing to late scar formation, do we intervene with medications?

Available Medication for the treatment of Peyronies:

• POTABA: or Potassium para amino benzoate is designated by the FDA as "possibly effective". Large doses are required, which may cause intestinal upset.
  
  
• VITAMIN E: It has been used for the treatment of scars, and has been employed in the treatment of Peyronie's disease since 1945.
  
  
• VERAPAMIL: is usually given by direct injection into the plaque. It also interferes with the synthesis of scar tissue precursors.
  
  
• COLLAGENASE: is an investigational drug that enzymatically digests scar.
  
  
• COLCHICINE: A popular medication for inflammation, it interferes with the manufacture of scar tissue.